IAP VII/39
T lymphocytes : from basic biology to immunotherapy
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Publications
Co-Publications

2016
  • Van Lint S, Renmans D, Broos K, Goethals L, Maenhout S, Benteyn D, Goyvaerts C, Du Four S, Van der Jeught K, BialkowskiL, Flamand V, Heirman C, Thielemans K, Breckpot K. Intratumoral Delivery of TriMix mRNA Results in T-cell Activation byCross-Presenting Dendritic Cells. Cancer Immunol Res. 2016 Feb;4(2):146-56. ULB-VUB
  • Wilgenhof S, Corthals J, Heirman C, van Baren N, Lucas S, Kvistborg P, Thielemans K, Neyns B. Phase II Study of Autologous Monocyte-Derived mRNA Electroporated Dendritic Cells (TriMixDC-MEL) Plus Ipilimumab in Patients With Pretreated Advanced Melanoma. J Clin Oncol. 2016 Apr 20;34(12):1330-8. UCL-VUB

2015
  • Dhaeze, T., Stinissen, P., Liston, A., and Hellings, N. Humoral autoimmunity: A failure of regulatory T cells? Autoimmun Reviews 2015. KULeuven-UHasselt
  • Janssens, K., Van den Haute, C., Baekelandt, V., Lucas, S., van Horssen, J., Somers, V., Van Wijmeersch, B., Stinissen, P., Hendriks, J.J., Slaets, H., and Hellings N. Leukemia inhibitory factor tips the immune balance towards regulatory T cells in multiple sclerosis. Brain Behavior and Immunity 2015. UCL-UHasselt
  • Dhaeze, T., Peelen, E., Hombrouck, A., Peeters, L., Van Wijmeersch, B., Lemkens, N., Lemkens, P., Somers, V., Lucas, S., Broux, B., Stinissen P., Hellings N. Circulating Follicular Regulatory T Cells Are Defective in Multiple Sclerosis. Journal of Immunology 2015. UCL-UHasselt
  • Dhainaut M, Coquerelle C, Uzureau S, Denoeud J, Acolty V, Oldenhove G, Galuppo A, Sparwasser T, Thielemans K, Pays E, Yagita H, Borst J, Moser M. Thymus-derived regulatory T cells restrain pro-inflammatory Th1 responses by downregulating CD70 on dendritic cells. EMBO J. 2015 May 12;34(10):1336-48. ULB-VUB
  • Put K, Avau A, Brisse E, Mitera T, Put S, Proost P, Bader-Meunier B, Westhovens R, Van den Eynde BJ, Orabona C, Fallarino F, De Somer L, Tousseyn T, Quartier P, Wouters C, Matthys P. Cytokines in systemic juvenile idiopathic arthritis and haemophagocytic lymphohistiocytosis: tipping the balance between interleukin-18 and interferon-γ. Rheumatology (Oxford). 2015 Mar 12. pii: keu524. (UCL-KULeuven)

2014
  • Avau A, Mitera T, Put S, Put K, Brisse E, Filtjens J, Uyttenhove C, Van Snick J, Liston A, Leclercq G, Billiau AD, Wouters CH, Matthys P. Systemic juvenile idiopathic arthritis-like syndrome in mice following stimulation of the immune system with Freund's complete adjuvant: regulation by interferon-γ. Arthritis Rheumatol. 2014 May;66(5):1340-51. KULeuven-UGent
  • Bol KF, Mensink HW, Aarntzen EH, Schreibelt G, Keunen JE, Coulie PG, de Klein A, Punt CJ, Paridaens D, Figdor CG, de Vries IJ. Long overall survival after dendritic cell vaccination in metastatic uveal melanoma patients. Am. J. Ophthalmol. 2014;158:939-47. UCL-RU
  • Demotte N, Bigirimana R, Wieers G, Stroobant V, Squifflet JL, Carrasco J, Thielemans K, Baurain JF, Van Der Smissen P, Courtoy PJ, van der Bruggen P. A short treatment with galactomannan GM-CT-01 corrects the functions of freshly isolated human tumor-infiltrating lymphocytes. Clin. Cancer Res. 2014;20:1823-33. VUB-UCL
  • Mayer A, Debuisson D, Denanglaire S, Eddahri F, Fievez L, Hercor M, Triffaux E, Moser M, Bureau F, Leo O, Andris F. Antigen presenting cell-derived IL-6 restricts Th2-cell differentiation. Eur J Immunol. 2014 Nov;44(11):3252-62. doi: 10.1002/eji.201444646. ULB-ULg
  • Rahir G, Wathelet N, Hanoteau A, Henin C, Oldenhove G, Galuppo A, Lanaya H, Colau D, Mackay CR, Van den Eynde B, Moser M. Cyclophosmamide treatment induces rejection of established P815 mastocytoma by enhancing CD4 priming and intratumoral infiltration of P1E/H-2K(d)-specific CD8 T cells. Int. J. Cancer 2014; 134:2841-2852. ULB-UCL
  • Marillier RG, Uyttenhove C, Goriely S, Marbaix E, Van Snick J. IL-27p28 is essential for parent-to-F1 acute graft-versus-host disease. Eur J Immunol. 2014 Apr 3. doi: 10.1002/eji.201444491. ULB-UCL
2013
  • Tel J, Aarntzen EH, Baba T, Schreibelt G, Schulte BM, Benitez-Ribas D, Boerman OC, Croockewit S, Oyen WJ, van Rossum M, Winkels G, Coulie PG, Punt CJ, Figdor CG, de Vries IJ. Natural human plasmacytoid dendritic cells induce antigen-specific T-cell responses in melanoma patients. Cancer Res. 2013 Feb 1;73(3):1063-75. UCL1-RU
2012
  • Snauwaert S, Vanhee S, Goetgeluk G, Verstichel G, Van Caeneghem Y, Velghe I, Philippé J, Berneman ZN, Plum J, Taghon T, Leclercq G, Thielemans K, Kerre T, Vandekerckhove B. RHAMM/HMMR (CD168) is not an ideal target antigen for immunotherapy of acute myeloid leukemia. Haematologica. 2012 Oct;97(10):1539-47. UGent-VUB
  • Van Nuffel AM, Benteyn D, Wilgenhof S, Pierret L, Corthals J, Heirman C, van der Bruggen P, Coulie PG, Neyns B, Thielemans K, Bonehill A. Dendritic cells loaded with mRNA encoding full-length tumor antigens prime CD4 and CD8 T cells in melanoma patients. Mol Ther. 2012 May;20(5):1063-74. doi: 10.1038/mt.2012.11. UCL1-VUB
  • Michelle Linterman, Adrian Liston and Carola G. Vinuesa. 'Follicular helper T cell differentiation and the co-option of this pathway by non-helper cells' 2012. Immunological Reviews. 247(1) p143. KULeuven-ANU
  • Vandenbroucke, R., Dejonckheere, E., Van Lint, P., Demeestere, D., Van Wonterghem, E., Vanlaere, I., Puimège, L., Van Hauwermeiren, F., De Rycke, R., Mc Guire, C., Campestre, C., López-Otin, C., Matthys, P., Leclercq, G., Libert, C. Matrix metalloprotease 8-dependent extracellular matrix cleavage at the blood-CSF narrier contributes to lethality during systemic inflammatory diseases. 2012. Journal of Neuroscience, 32(29), 9805-9816. KULeuven-UGent