IAP VII/39
T lymphocytes : from basic biology to immunotherapy
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Publications
Publications

2016
  • Preyat N, Leo O. Complex role of nicotinamide adenine dinucleotide in the regulation of programmed cell death pathways. Biochem Pharmacol. 2016 Feb 1;101:13-26.
  • Torres D, Köhler A, Delbauve S, Caminschi I, Lahoud MH, Shortman K, Flamand V. IL-12p40/IL-10 Producing preCD8α/Clec9A Dendritic Cells Are Induced in Neonates upon Listeria monocytogenes Infection. PLoS Pathog. 2016 Apr 13;12(4):e1005561.
  • Van Lint S, Renmans D, Broos K, Goethals L, Maenhout S, Benteyn D, Goyvaerts C, Du Four S, Van der Jeught K, Bialkowski L, Flamand V, Heirman C, Thielemans K, Breckpot K. Intratumoral Delivery of TriMix mRNA Results in T-cell Activation by Cross-Presenting Dendritic Cells. Cancer Immunol Res. 2016 Feb;4(2):146-56.
  • Wilgenhof S, Corthals J, Heirman C, van Baren N, Lucas S, Kvistborg P, Thielemans K, Neyns B. Phase II Study of Autologous Monocyte-Derived mRNA Electroporated Dendritic Cells (TriMixDC-MEL) Plus Ipilimumab in Patients With Pretreated Advanced Melanoma. J Clin Oncol. 2016 Apr 20;34(12):1330-8.
  • Bialkowski L, van Weijnen A, Van der Jeught K, Renmans D, Daszkiewicz L, Heirman C, Stangé G, Breckpot K, Aerts JL, Thielemans K. Intralymphatic mRNA vaccine induces CD8 T-cell responses that inhibit the growth of mucosally located tumours. Sci Rep. 2016 Mar 2;6:22509.
  • Cochez PM, Michiels C, Hendrickx E, Van Belle AB, Lemaire MM, Dauguet N, Warnier G, de Heusch M, Togbe D, Ryffel B, Coulie PG, Renauld JC, Dumoutier L. AhR modulates the IL-22 producing cell proliferation/recruitment in imiquimod-induced psoriasis mouse model. Eur J Immunol. 2016 Mar 22.
  • Wilgenhof S, Corthals J, Heirman C, van Baren N, Lucas S, Kvistborg P, Thielemans K, Neyns B. Phase II Study of Autologous Monocyte-Derived mRNA Electroporated Dendritic Cells (TriMixDC-MEL) Plus Ipilimumab in Patients With Pretreated Advanced Melanoma. J Clin Oncol. 2016 Apr 20;34(12):1330-8.
  • Van de Walle I, Dolens AC, Durinck K, De Mulder K, Van Loocke W, Damle S, Waegemans E, De Medts J, Velghe I, De Smedt M, Vandekerckhove B, Kerre T, Plum J, Leclercq G, Rothenberg EV, Van Vlierberghe P, Speleman F, Taghon T. GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate. Nat Commun. 2016 Apr 6;7:11171.
  • Vanhee S, Vandekerckhove B. Pluripotent stem cell based gene therapy for hematological diseases. Crit Rev Oncol Hematol. 2016 Jan;97:238-46.
  • Brisse E, Imbrechts M, Put K, Avau A, Mitera T, Berghmans N, Rutgeerts O, Waer M, Ninivaggi M, Kelchtermans H, Boon L, Snoeck R, Wouters CH, Andrei G, Matthys P. Mouse Cytomegalovirus Infection in BALB/c Mice Resembles Virus-Associated Secondary Hemophagocytic Lymphohistiocytosis and Shows a Pathogenesis Distinct from Primary Hemophagocytic Lymphohistiocytosis. J Immunol. 2016 Apr 1;196(7):3124-34.
  • Masters SL, Lagou V, Jéru I, Baker PJ, Van Eyck L, Parry DA, Lawless D, De Nardo D, Garcia-Perez JE, Dagley LF, Holley CL, Dooley J, Moghaddas F, Pasciuto E, Jeandel PY, Sciot R, Lyras D, Webb AI, Nicholson SE, De Somer L, van Nieuwenhove E, Ruuth-Praz J, Copin B, Cochet E, Medlej-Hashim M, Megarbane A, Schroder K, Savic S, Goris A, Amselem S, Wouters C, Liston A. Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation. Sci Transl Med. 2016 Mar 30;8(332):332ra45.
  • Put K, Brisse E, Avau A, Imbrechts M, Mitera T, Janssens R, Proost P, Fallarino F, Wouters CH, Matthys P. IDO1 Deficiency Does Not Affect Disease in Mouse Models of Systemic Juvenile Idiopathic Arthritis and Secondary Hemophagocytic Lymphohistiocytosis. PLoS One. 2016 Feb 25;11(2):e0150075.
2015
  • Shehade H, Acolty V, Moser M, Oldenhove G. Cutting Edge: Hypoxia-Inducible Factor 1 Negatively Regulates Th1 Function. J Immunol. 2015 Aug 15;195(4):1372-6.
  • Weatherly K, Bettonville M, Torres D, Kohler A, Goriely S, Braun MY. Functional profile of S100A4-deficient T cells. Immun Inflamm Dis. 2015 Sep 25;3(4):431-44.
  • Zhang J, Vandevenne P, Hamdi H, Van Puyvelde M, Zucchi A, Bettonville M, Weatherly K, Braun MY. Micro-RNA-155-mediated control of heme oxygenase 1 (HO-1) is required for restoring adaptively tolerant CD4 T-cell function in rodents. Eur J Immunol. 2015 Mar;45(3):829-42.
  • Zhang J, Braun MY. Protoporphyrin Treatment Modulates Susceptibility to Experimental Autoimmune Encephalomyelitis in miR-155-Deficient Mice. PLoS One.2015 Dec 15;10(12):e0145237.
  • Goyvaerts C, Broos K, Escors D, Heirman C, Raes G, De Baetselier P, Thielemans K, Breckpot K. The transduction pattern of IL-12-encoding lentiviral vectors shapes the immunological outcome. Eur J Immunol. 2015 Dec;45(12):3351-61.
  • Dufait I, Schwarze JK, Liechtenstein T, Leonard W, Jiang H, Escors D, De Ridder M, Breckpot K. Ex vivo generation of myeloid-derived suppressor cells that model the tumor immunosuppressive environment in colorectal cancer. Oncotarget. 2015 May 20;6(14):12369-82
  • van Baren N, Van den Eynde BJ. Tumoral Immune Resistance Mediated by Enzymes That Degrade Tryptophan. Cancer Immunol Res. 2015 Sep;3(9):978-85.
  • Vigneron N, Abi Habib J, Van den Eynde BJ. The capture proteasome assay (CAPA) to evaluate subtype-specific proteasome inhibitors. Data Brief. 2015 May 18;4:146-51.
  • Huygens C, Liénart S, Dedobbeleer O, Stockis J, Gauthy E, Coulie PG, Lucas S. Lysosomal-associated Transmembrane Protein 4B (LAPTM4B) Decreases Transforming Growth Factor β1 (TGF-β1) Production in Human Regulatory T Cells. J Biol Chem.2015 Aug 14;290(33):20105-16.
  • Vigneron N, Abi Habib J, Van den Eynde BJ. The capture proteasome assay: A method to measure proteasome activity in vitro. Anal Biochem. 2015 Aug 1;482:7-15.
  • Avau A, Matthys P. Therapeutic Potential of Interferon-γ and Its Antagonists in Autoinflammation: Lessons from Murine Models of Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome. Pharmaceuticals (Basel). 2015 Nov 25;8(4):793-815.
  • Put K, Avau A, Brisse E, Mitera T, Put S, Proost P, Bader-Meunier B, Westhovens R, Van den Eynde BJ, Orabona C, Fallarino F, De Somer L, Tousseyn T, Quartier P, Wouters C, Matthys P. Cytokines in systemic juvenile idiopathic arthritis and haemophagocytic lymphohistiocytosis: tipping the balance between interleukin-18 and interferon-γ. Rheumatology (Oxford). 2015 Aug;54(8):1507-17.
  • Janssens K, Maheshwari A, Van den Haute C, Baekelandt V, Stinissen P, Hendriks JJ, Slaets H, Hellings N. Oncostatin M protects against demyelination by inducing a protective microglial phenotype. Glia. 2015 Oct;63(10):1729-37.
  • Dhaeze T, Stinissen P, Liston A, Hellings N. Humoral autoimmunity: a failure of regulatory T cells? Autoimmun Rev. 2015 Aug;14(8):735-41.
  • Dhaeze T, Peelen E, Hombrouck A, Peeters L, Van Wijmeersch B, Lemkens N, Lemkens P, Somers V, Lucas S, Broux B, Stinissen P, Hellings N. Circulating Follicular Regulatory T Cells Are Defective in Multiple Sclerosis. J Immunol. 2015 Aug 1;195(3):832-40.
  • Martinet V, Tonon S, Torres D, Azouz A, Nguyen M, Kohler A, Flamand V, Mao CA, Klein WH, Leo O, Goriely S. Type I interferons regulate eomesodermin expression and the development of unconventional memory CD8( ) T cells. Nat Commun. 2015 May 8;6:7089. doi: 10.1038/ncomms8089.
  • Dimova T, Brouwer M, Gosselin F, Tassignon J, Leo O, Donner C, Marchant A, Vermijlen D. Effector Vγ9Vδ2 T cells dominate the human fetal γδ T-cell repertoire. Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):E556-65. doi:10.1073/pnas.1412058112.
  • Dhainaut M, Coquerelle C, Uzureau S, Denoeud J, Acolty V, Oldenhove G, Galuppo A, Sparwasser T, Thielemans K, Pays E, Yagita H, Borst J, Moser M. Thymus-derived regulatory T cells restrain pro-inflammatory Th1 responses by downregulating CD70 on dendritic cells. EMBO J. 2015 May 12;34(10):1336-48. doi: 10.15252/embj.201490312
  • Tounsi N, Meghari S, Moser M, Djerdjouri B. Lysophosphatidylcholine exacerbates Leishmania major-dendritic cell infection through interleukin-10 and a burst in arginase1 and indoleamine 2,3-dioxygenase activities. Int Immunopharmacol. 2015 Mar;25(1):1-9. doi: 10.1016/j.intimp.2015.01.006.
  • Zhang J, Vandevenne P, Hamdi H, Van Puyvelde M, Zucchi A, Bettonville M, Weatherly K, Braun MY. Micro-RNA-155-mediated control of heme oxygenase 1 (HO-1) is required for restoring adaptively tolerant CD4 T-cell function in rodents. Eur J Immunol. 2015 Mar;45(3):829-42. doi: 10.1002/eji.201445066.
  • Dhainaut M, Coquerelle C, Uzureau S, Denoeud J, Acolty V, Oldenhove G, Galuppo A, Sparwasser T, Thielemans K, Pays E, Yagita H, Borst J, Moser M. Thymus-derived regulatory T cells restrain pro-inflammatory Th1 responses by downregulating CD70 on dendritic cells. EMBO J. 2015 May 12;34(10):1336-48. doi: 10.15252/embj.201490312
  • Van der Jeught K, Bialkowski L, Daszkiewicz L, Broos K, Goyvaerts C, Renmans D, Van Lint S, Heirman C, Thielemans K, Breckpot K. Targeting the tumor microenvironment to enhance antitumor immune responses. Oncotarget. 2015 Jan 30;6(3):1359-81.
  • Wilgenhof S, Corthals J, Van Nuffel AM, Benteyn D, Heirman C, Bonehill A, Thielemans K, Neyns B. Long-term clinical outcome of melanoma patients treated with messenger RNA-electroporated dendritic cell therapy following complete resection of metastases. Cancer Immunol Immunother. 2015 Mar;64(3):381-8. doi:10.1007/s00262-014-1642-8.
  • Van Lint S, Renmans D, Broos K, Dewitte H, Lentacker I, Heirman C, Breckpot K, Thielemans K. The ReNAissanCe of mRNA-based cancer therapy. Expert Rev Vaccines. 2015 Feb;14(2):235-51. doi: 10.1586/14760584.2015.957685.
  • Benteyn D, Heirman C, Bonehill A, Thielemans K, Breckpot K. mRNA-based dendritic cell vaccines. Expert Rev Vaccines. 2015 Feb;14(2):161-76. doi: 10.1586/14760584.2014.957684.
  • Kleiman E, Salyakina D, De Heusch M, Hoek KL, Llanes JM, Castro I, Wright JA, Clark ES, Dykxhoorn DM, Capobianco E, Takeda A, Renauld JC, Khan WN. Distinct Transcriptomic Features are Associated with Transitional and Mature B-Cell Populations in the Mouse Spleen. Front Immunol. 2015 Feb 11;6:30. doi: 10.3389/fimmu.2015.00030.
  • Cuende J, Lienart S, Dedobbeleer O, van der Woning B, De Boeck G, Stockis J, Huygens C, Colau D, Somja J, Delvenne P, Hannon M, Baron F, Dumoutier L, Renauld JC, De Haard H, Saunders M, Coulie PG, Lucas S. Monoclonal antibodies against GARP/TGF-beta1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo. Sci. Transl. Med. 2015;7:284ra56.
  • Vigneron N, Abi Habib J, Van den Eynde BJ. The capture proteasome assay: A method to measure proteasome activity in vitro. Anal. Biochem. 2015;482:7-15.
  • Arts N, Cane S, Hennequart M, Lamy J, Bommer G, Van den Eynde B, De Plaen E. microRNA-155, induced by interleukin-1ss, represses the expression of microphthalmia-associated transcription factor (MITF-M) in melanoma cells. PLoS One 2015;10:e0122517.
  • Van Baren N, Van den Eynde BJ. Tryptophan-degrading enzymes in tumoral immune resistance. Front. Immunol. 2015;6:34.
  • Theate I, van Baren N, Pilotte L, Moulin P, Larrieu P, Renauld JC, Herve C, Gutierrez-Roelens I, Marbaix E, Sempoux C, Van den Eynde BJ. Extensive profiling of the expression of the indoleamine 2,3-dioxygenase 1 protein in normal and tumoral human tissues. Cancer Immunol. Res. 2015;3:161-72.
  • Vanhee S, De Mulder K, Van Caeneghem Y, Verstichel G, Van Roy N, Menten B, Velghe I, Philippé J, De Bleser D, Lambrecht BN, Taghon T, Leclercq G, Kerre T, Vandekerckhove B. In vitro human embryonic stem cell hematopoiesis mimics MYB-independent yolk sac hematopoiesis. Haematologica. 2015 Feb;100(2):157-66. doi: 10.3324/haematol.2014.112144
  • Dhaeze T, Stinissen P, Liston A, Hellings N. Humoral autoimmunity: A failure of regulatory T cells? Autoimmun Rev. 2015 Aug;14(8):735-741. doi: 10.1016/j.autrev.2015.04.006.
  • Put K, Avau A, Brisse E, Mitera T, Put S, Proost P, Bader-Meunier B, Westhovens R, Van den Eynde BJ, Orabona C, Fallarino F, De Somer L, Tousseyn T, Quartier P, Wouters C, Matthys P. Cytokines in systemic juvenile idiopathic arthritis and haemophagocytic lymphohistiocytosis: tipping the balance between interleukin-18 and interferon-γ. Rheumatology (Oxford). 2015 Mar 12. pii: keu524.
  • Brisse E, Wouters CH, Matthys P. Hemophagocytic lymphohistiocytosis (HLH): A heterogeneous spectrum of cytokine-driven immune disorders. Cytokine Growth Factor Rev. 2015 Jun;26(3):263-280. doi: 10.1016/j.cytogfr.2014.10.001.
  • Avau A, Put K, Wouters CH, Matthys P. Cytokine balance and cytokine-driven natural killer cell dysfunction in systemic juvenile idiopathic arthritis. Cytokine Growth Factor Rev. 2015 Feb;26(1):35-45. doi:10.1016/j.cytogfr.2014.05.005.
  • Dhaeze, T., Stinissen, P., Liston, A., and Hellings, N. Humoral autoimmunity: A failure of regulatory T cells? Autoimmun Reviews 2015.
  • Broux, B., Mizee, M.R., Vanheusden, M., van der Pol, S., van Horssen, J., Van Wijmeersch, B., Somers, V., de Vries, H.E., Stinissen, P., and Hellings, N. 2015. IL-15 amplifies the pathogenic properties of CD4 CD28- T cells in multiple sclerosis. Journal of Immunology 2015.
  • Vanheusden, M., Stinissen, P., t Hart, B.A., and Hellings, N. 2015. Cytomegalovirus: a culprit or protector in multiple sclerosis? Trends Molecular Medicine 2015.
  • Janssens, K., Van den Haute, C., Baekelandt, V., Lucas, S., van Horssen, J., Somers, V., Van Wijmeersch, B., Stinissen, P., Hendriks, J.J., Slaets, H., and Hellings N. Leukemia inhibitory factor tips the immune balance towards regulatory T cells in multiple sclerosis. Brain Behavior and Immunity 2015.
  • Dhaeze, T., Peelen, E., Hombrouck, A., Peeters, L., Van Wijmeersch, B., Lemkens, N., Lemkens, P., Somers, V., Lucas, S., Broux, B., Stinissen P., Hellings N. Circulating Follicular Regulatory T Cells Are Defective in Multiple Sclerosis. Journal of Immunology 2015.
2014

  • Mayer A, Debuisson D, Denanglaire S, Eddahri F, Fievez L, Hercor M, Triffaux E, Moser M, Bureau F, Leo O, Andris F. Antigen presenting cell-derived IL-6 restricts Th2-cell differentiation. Eur J Immunol. 2014 Nov;44(11):3252-62. doi: 10.1002/eji.201444646.
  • Welsby I, Hutin D, Gueydan C, Kruys V, Rongvaux A, Leo O. PARP12, an interferon-stimulated gene involved in the control of protein translation and inflammation. J Biol Chem. 2014 Sep 19;289(38):26642-57. doi: 10.1074/jbc.M114.589515.
  • Gordon-Alonso M, Demotte N, van der Bruggen P. Sugars boost exhausted tumor-infiltrating lymphocytes by counteracting immunosuppressive activities of galectins. Oncoimmunology 2014;3:e28783.
  • Vigneron N, Van den Eynde BJ. Proteasome subtypes and regulators in the processing of antigenic peptides presented by class I molecules of the major histocompatibility complex. Biomolecules 2014;4:994-1025.
  • Shehade H, Oldenhove G, Moser M. Hypoxia in the intestine or solid tumors: a beneficial or deleterious alarm signal? Eur J Immunol. 2014 Sep;44(9):2550-7. doi: 10.1002/eji.201444719.
  • De Kleer I, Willems F, Lambrecht B, Goriely S. Ontogeny of myeloid cells. Front Immunol. 2014 Sep 3;5:423. doi: 10.3389/fimmu.2014.00423.
  • Van der Jeught K, Joe PT, Bialkowski L, Heirman C, Daszkiewicz L, Liechtenstein T, Escors D, Thielemans K, Breckpot K. Intratumoral administration of mRNA encoding a fusokine consisting of IFN-β and the ectodomain of the TGF-β receptor II potentiates antitumor immunity. Oncotarget. 2014 Oct 30;5(20):10100-13.
  • Springuel L, Hornakova T, Losdyck E, Lambert F, Leroy E, Constantinescu SN, Flex E, Tartaglia M, Knoops L, Renauld JC. Cooperating JAK1 and JAK3 mutants increase resistance to JAK inhibitors. Blood. 2014 Dec 18;124(26):3924-31. doi: 10.1182/blood-2014-05-576652.
  • Bol KF, Mensink HW, Aarntzen EH, Schreibelt G, Keunen JE, Coulie PG, de Klein A, Punt CJ, Paridaens D, Figdor CG, de Vries IJ. Long overall survival after dendritic cell vaccination in metastatic uveal melanoma patients. Am. J. Ophthalmol. 2014;158:939-47.
  • Abad S, Wieers G, Colau D, Wildmann C, Delair E, Dhote R, Brezin AP, Kawakami Y, Coulie PG, van der Bruggen P. Absence of recognition of common melanocytic antigens by T cells isolated from the cerebrospinal fluid of a Vogt-Koyanagi-Harada patient. Mol. Vis. 2014;20:956-69.
  • Ysebrant de Lendonck L, Martinet V, Goriely S. Interferon regulatory factor 3 in adaptive immune responses. Cell Mol Life Sci. 2014 May 31. [Epub ahead of print] PubMed PMID: 24879293.
  • Marillier RG, Uyttenhove C, Goriely S, Marbaix E, Van Snick J. IL-27p28 is essential for parent-to-F1 acute graft-versus-host disease. Eur J Immunol. 2014 Apr 3. doi: 10.1002/eji.201444491. [Epub ahead of print] PubMed PMID: 24700119.
  • Van Lint S, Wilgenhof S, Heirman C, Corthals J, Breckpot K, Bonehill A, Neyns B, Thielemans K. Optimized dendritic cell-based immunotherapy for melanoma: the TriMix-formula. Cancer Immunol Immunother. 2014 May 31. [Epub ahead of print] PubMed PMID: 24878889.
  • Goyvaerts C, Kurt de G, Van Lint S, Heirman C, Van Ginderachter JA, De Baetselier P, Raes G, Thielemans K, Breckpot K. Immunogenicity of targeted lentivectors. Oncotarget. 2014 Feb 15;5(3):704-15. PubMed PMID: 24519916; PubMed Central PMCID: PMC3996667.
  • Michaux A, Larrieu P, Stroobant V, Fonteneau JF, Jotereau F, Van den Eynde BJ, Moreau-Aubry A, Vigneron V. A spliced antigenic peptide comprising a single spliced amino acid is produced in the proteasome by reverse splicing of a longer peptide fragment followed by trimming. J. Immunol. 2014;192:1962-71.
  • Coulie PG, Van den Eynde BJ, van der Bruggen P, Boon T. Tumour antigens recognized by T lymphocytes: at the core of cancer immunotherapy. Nat. Rev. Cancer 2014; 14:135-46.
  • Demotte N, Bigirimana R, Wieërs G, Stroobant V, Squifflet JL, Carrasco J, Thielemans K, Baurain JF, Van Der Smissen P, Courtoy PJ, van der Bruggen P. A short treatment with galactomannan GM-CT-01 corrects the functions of freshly isolated human tumor-infiltrating lymphocytes. Clin. Cancer Res. 2014; 20:1823-1833.
  • Buysschaert M, Baeck M, Preumont V, Marot L, Hendrickx E, Van Belle A, Dumoutier L. Improvement of psoriasis during GLP-1 analogue therapy in type 2 diabetes is associated with decreasing dermal γδ T cells number: a prospective case series study. Br J Dermatol. 2014 Feb 7.
  • Waegemans E, Van de Walle I, De Medts J, De Smedt M, Kerre T, Vandekerckhove B, Leclercq G, Wang T, Plum J, Taghon T. Notch3 activation is sufficient but not required for inducing human T-lineage specification. J Immunol. 2014 Dec 15;193(12):5997-6004. doi: 10.4049/jimmunol.1400764.
  • Filtjens J., Foquet L., Taveirne S., Van Ammel E., Vanhees M., Van Acker A., Kerre T., Taghon T., Vandekerckhove B., Plum J., Van den Steen P. and Leclercq G. The role of the Ly49E NK receptor in Plasmodium berghei infection PLOS ONE, 2014, 9 (1): e87463
  • Avau A., Mitera T., Put S., Put K., Brisse E., Filtjens J., Uyttenhove C., Van Snick J., Liston A., Leclercq G., Billiau A.D., Wouters C. and Matthys P. Systemic juvenile idiopathic arthritis-like syndrome in mice following stimulation of the immune system with Freund's adjuvant: regulation by IFN-γ. Arthritis and Rheumatism, 2014, 66: 1340-1351.
  • Mets E, Van Peer G, Van der Meulen J, Boice M, Taghon T, Goossens S, Mestdagh P, Benoit Y, De Moerloose B, Van Roy N, Poppe B, Vandesompele J, Wendel HG, Van Vlierberghe P, Speleman F, Rondou P. MicroRNA-128-3p is a novel oncomiR targeting PHF6 in T-cell acute lymphoblastic leukemia. Haematologica. 2014 Jun 3. pii: haematol.2013.099515.
  • Pyfferoen L, Mestdagh P, Vergote K, De Cabooter N, Vandesompele J, Lambrecht BN, Vermaelen KY. Lung tumours reprogram pulmonary dendritic cell immunogenicity at the microRNA level. Int J Cancer. 2014 May 2. doi: 10.1002/ijc.28945
  • Bénédicte Cauwe, Lei Tian, Dean Franckaert, Wim Pierson, Kim Staats, Susan Schlenner and Adrian Liston. ‘A novel Zap70 mutation with reduced protein stability demonstrates the rate-limiting threshold for Zap70 in T cell receptor signalling’. 2014. Immunology. 141(3) p377.
  • Owen M. Siggs, Adele L. Yates, Susan Schlenner, Adrian Liston, Sylvie Lesage, Christopher C. Goodnow. ‘A ZAP-70 kinease domain variant prevents thymocyte positive selection despite signalling CD69 induction’. 2014. Immunology. 141(3) p377.
  • Christian T. Mayer, Julia Huntenburg, Lei Tian, Amrita Nandan, Anja Kuhl, Christina Hesse, Edgar Schmitt, Adrian Liston and Tim Sparwasser. ‘Anti-CD4 treatment inhibits autoimmunity in scurfy mice through the attenuation of co-stimulatory signals’. 2014. Journal of Autoimmunity. 50 p23.
  • Pedro J. Gomez-Pinilla, Giovanna Farro, Martina Di Giovangiulio, Nathalie Stakenborg, Andrea Nemethova, Annick de Vries, Adrian Liston, Thorsten B. Feyerabend, Hans-Reimer Rodewald, Guy E. Boeckxstaens and Gianluca Matteoli. ‘Mast cells play no role in the pathogenesis of postoperative ileus induced by intestinal manipulation’. 2014. PLoS One. 9(1) e85304.
  • V. Dugas, A. Liston, E.E. Hillhouse, R. Collin, G. Chabot-Roy, A.N. Pelletier, C. Beauchamp, K. Hardy and S. Lesage. ‘Idd13 is involved in determining immunoregulatory DN T-cell number in NOD mice’. 2014. Genes and Immunity. 15(2) p82.
  • M.S. Carlon, D. Vidovic, J. Dooley, M. Mori da Cunha, M. Maris, Y. Lampi, J. Toelen, C. Van den Haute, V. Baekelandt, J. Deprest, E. Verbeken, A. Liston, R. Gijsbers and Z. Debyser. ‘Immunological ignorance allows long-term gene expression after perinatal recombinant adeno-associated virus-mediated gene transfer to murine airways’. 2014. Human Gene Therapy. In press.
  • Adrian Liston and Daniel H. Gray. ‘Homeostatic control of regulatory T cell diversity’. 2014. Nature Reviews Immunology. 14(3) p154.
  • Daniel H. Gray and Adrian Liston. ‘Uhrf to Treg cells: reinforcing the mucosal peacekeepers’. 2014. Nature Immunology. 15(6) p533.
  • Fang Zheng, Stéphanie Put, Luc Bouwens, Tony Lahoutte, Patrick Matthys, Serge Muyldermans, Patrick De Baetselier, Nick Devoogdt, Geert Raes, and Steve Schoonooghe. ‘Molecular imaging with macrophage VSIG4-targeting Nbs for diagnosis and prognosis in mouse models of rheumatoid arthritis’. 2014. Journal of Nuclear Medicine. 55(5) p824.
  • Pannemans K, Broux B, Goris A, Dubois B, Broekmans T, Van Wijmeersch B, Geraghty D, Stinissen P, Hellings N. HLA-E restricted CD8 T cell subsets are phenotypically altered in multiple sclerosis patients. Mult Scler. 2014; Jun; 20(7): 790-801 *equal contribution. (IF: 4.472)
  • Thewissen K*, Nuyts AH*, Deckx N, Van Wijmeersch B, Nagels G, D'hooghe M, Willekens B, Cras P, Eijnde BO, Goossens H, Van Tendeloo VF, Stinissen P,Berneman ZN, Hellings N*, Cools N*. Circulating dendritic cells of multiple sclerosis patients are proinflammatory and their frequency is correlated with MS-associated genetic risk factors. Mult Scler. 2014 Apr;20(5):548-57. (IF: 4.472). *equal contribution.
  • Snauwaert S, Verstichel G, Bonte S, Goetgeluk G, Vanhee S, Van Caeneghem Y, De Mulder K, Heirman C, Stauss H, Heemskerk MH, Taghon T, Leclercq G, Plum J, Langerak AW, Thielemans K, Kerre T, Vandekerckhove B. In vitro generation of mature, naive antigen-specific CD8( ) T cells with a single T-cell receptor by agonist selection. Leukemia. 2014 Apr;28(4):830-41. doi: 10.1038/leu.2013.285
2013
  • Debuisson D, Mari N, Denanglaire S, Leo O, Andris F. Myor/ABF-1 Mrna expression marks follicular helper T cells but is dispensable for Tfh cell differentiation and function in vivo. PLoS One. 2013 Dec 26;8(12):e84415. doi: 10.1371/journal.pone.0084415. eCollection 2013. PubMed PMID: 24386375; PubMed Central PMCID: PMC3873420.
  • Molle C, Zhang T, Ysebrant de Lendonck L, Gueydan C, Andrianne M, Sherer F, Van Simaeys G, Blackshear PJ, Leo O, Goriely S. Tristetraprolin regulation of interleukin 23 mRNA stability prevents a spontaneous inflammatory disease. J Exp Med. 2013 Aug 26;210(9):1675-84. doi: 10.1084/jem.20120707. Epub 2013 Aug 12. PubMed PMID: 23940256; PubMed Central PMCID: PMC3754859.
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  • Debock I, Jaworski K, Chadlaoui H, Delbauve S, Passon N, Twyffels L, Leo O, Flamand V. Neonatal follicular Th cell responses are impaired and modulated by IL-4. J Immunol. 2013 Aug 1;191(3):1231-9. doi: 10.4049/jimmunol.1203288. Epub 2013 Jun 26. PubMed PMID: 23804713.
  • Mari N, Hercor M, Denanglaire S, Leo O, Andris F. The capacity of Th2 lymphocytes to deliver B-cell help requires expression of the transcription factor STAT3. Eur J Immunol. 2013 Jun;43(6):1489-98. doi: 10.1002/eji.201242938. Epub 2013 Apr 19. PubMed PMID: 23504518.
  • Preyat N, Leo O. Sirtuin deacylases: a molecular link between metabolism and immunity. J Leukoc Biol. 2013 May;93(5):669-80. doi: 10.1189/jlb.1112557. Epub 2013 Jan 16. Review. PubMed PMID: 23325925.
  • Compté N, Boudjeltia KZ, Vanhaeverbeek M, De Breucker S, Pepersack T, Tassignon J, Trelcat A, Goriely S. Increased basal and alum-induced interleukin-6 levels in geriatric patients are associated with cardiovascular morbidity. PLoS One. 2013 Nov 14;8(11):e81911. doi: 10.1371/journal.pone.0081911. eCollection 2013. PubMed PMID: 24244750; PubMed Central PMCID: PMC3828251.
  • Compté N, Zouaoui Boudjeltia K, Vanhaeverbeek M, De Breucker S, Tassignon J, Trelcat A, Pepersack T, Goriely S. Frailty in old age is associated with decreased interleukin-12/23 production in response to toll-like receptor ligation. PLoS One. 2013 Jun 5;8(6):e65325. doi: 10.1371/journal.pone.0065325. Print 2013. PubMed PMID: 23755218; PubMed Central PMCID:
  • Benteyn D, Anguille S, Van Lint S, Heirman C, Van Nuffel AM, Corthals J, Ochsenreither S, Waelput W, Van Beneden K, Breckpot K, Van Tendeloo V, Thielemans K, Bonehill A. Design of an Optimized Wilms' Tumor 1 (WT1) mRNA Construct for Enhanced WT1 Expression and Improved Immunogenicity In Vitro and In Vivo. Mol Ther Nucleic Acids. 2013 Nov 19;2:e134. doi: 10.1038/mtna.2013.54. PubMed PMID: 24253259; PubMed Central PMCID: PMC3889186.
  • Goyvaerts C, Dingemans J, De Groeve K, Heirman C, Van Gulck E, Vanham G, De Baetselier P, Thielemans K, Raes G, Breckpot K. Targeting of human antigen-presenting cell subsets. J Virol. 2013 Oct;87(20):11304-8. doi:10.1128/JVI.01498-13. Epub 2013 Jul 17. PubMed PMID: 23864630;
  • Benteyn D, Van Nuffel AM, Wilgenhof S, Corthals J, Heirman C, Neyns B, Thielemans K, Bonehill A. Characterization of CD8 T-cell responses in the peripheral blood and skin injection sites of melanoma patients treated with mRNA electroporated autologous dendritic cells (TriMixDC-MEL). Biomed Res Int.2013;2013:976383. doi: 10.1155/2013/976383. Epub 2013 Jan 3. PubMed PMID: 23509826; PubMed Central PMCID: PMC3581259.
  • Van Lint S, Heirman C, Thielemans K, Breckpot K. mRNA: From a chemical blueprint for protein production to an off-the-shelf therapeutic. Hum Vaccin Immunother. 2013 Feb;9(2):265-74. Epub 2013 Jan 4. PubMed PMID: 23291946; PubMed Central PMCID: PMC3859745.
  • van Baren N, Coulie PG. Ongoing adaptive immune responses in the microenvironment of melanoma metastases. Ann. NY Acad. Sci. 2013; 1284:62-5.
  • van Baren N, Baurain JF, Coulie PG. Lymphoid neogenesis in melanoma: What does it tell us ? Oncoimmunology 2013; 2:e22505.
  • Vigneron N, Ma W, Michaux A, Van den Eynde BJ. Identifying source proteins for MHC class I-presented peptides. Methods Mol. Biol. 2013; 960:187-207.
  • Vigneron N, Stroobant V, Van den Eynde BJ, van der Bruggen P. Database of T-cell defined human tumor antigens: the 2013 update. Cancer Immun. 2013; 13:15.
  • Gauthy E, Cuende J, Stockis J, Huygens C, Lethe B, Collet JF, Bommer G, Coulie PG, Lucas S. GARP is regulated by miRNAs and controls latent TGF-beta1 production by human regulatory T cells. PLoS One 2013;8:e76186.
  • Behrends, J., Renauld, J.-C., Ehlers, S., and Hölscher C. IL-22 is mainly produced by IFNg-secreting cells but is dispensable for host protection against Mycobacterium tuberculosis infection. PLoS One. 8:e57379, 2013.
  • Guabiraba, R., Besnard, A.G., Marques, R.E., Maillet, I., Fagundes, C.T., Conceiçao, T.M., Rust, N.M., Charreau, S., Paris, I., Lecron, J.C., Renauld, J.-C., Quesniaux, V., Da Poian, A.T., Arruda, L.B., Souza, D.G., Ryffel, B., and Teixeira, M.M. IL-22 modulates IL-17A production and controls inflammation and tissue damage in experimental dengue infection. Eur. J. Immunol. 43 : 1529-1544, 2013.
  • Ivanov S, Renneson J, Fontaine J, Barthelemy A, Paget C, Fernandez EM, Blanc F, De Trez C, Van Maele L, Dumoutier L, Huerre MR, Eberl G, Si-Tahar M, Gosset P, Renauld JC, Sirard JC, Faveeuw C, Trottein F. Interleukin-22 Reduces Lung Inflammation during Influenza A Virus Infection and Protects against Secondary Bacterial Infection. J Virol. 87:6911-6924, 2013.
  • Kumari, S., Bonnet, M., Ulvmar, M.H., Wolk, K., Karagianni, N., Witte, E, Uthoff-Hachenberg, C., Renauld, J.-C., Kollias, G., Toftgard, R., Sabat, R., Pasparakis, M., and Haase, I. TNFR1 signaling in NF-κB-deficient keratinocytes triggers IL-24-dependent psoriasis-like skin inflammation in mice. Immunity. 39 : 899-911, 2013.
  • Renauld J.-C., and Dumoutier L. Contributions of IL-22 to TH17 responses : repairing and protecting peripheral tissues. In : IL-17, IL-22 and their producing cells cells : Role in inflammation and autoimmunity, V. Quesniaux, B. Ryffel and F. di Padova (Eds.), Series : Progress in Inflammation Research. 2nd edition. 55-70, 2013.
  • Turner, J.E., Wilhelm, C., Wilson, M., Ahlfors, H., Renauld, J.-C., Panzer, U., Helmby, H., Stockinger, B., and Morrison, P. IL-9-mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation. J. Exp. Med. 210 : 2951-2965, 2013.
  • Van Den Broeck T., Van Ammel E., Delforche M., Taveirne S., Kerre T, Vandekerckhove B., Taghon T., Plum J. and Leclercq G. Differential Ly49e expression pathways in resting versus T cell receptor-activated intraepithelial γδ T cells. J. Immunol. 2013, 190: 1982–1990.
  • Filtjens J*, Taveirne S*, Van Acker A, Van Ammel E, Vanhees M, Kerre T, Taghon T, Vandekerckhove B, Plum J and Leclercq G. Abundant stage-dependent Ly49E expression by liver NK cells is not essential for their differentiation and function. J. Leukoc. Biol., 2013, 93: 699-711.
  • Van de Walle I, Waegemans E, De Medts J, De Smet G, De Smedt M, Snauwaert S, Vandekerckhove B, Kerre T, Leclercq G, Plum J, Gridley T, Wang T, Koch U, Radtke F, Taghon T. Specific Notch receptor-ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength. J Exp Med. 2013 Apr 8;210(4):683-97.
  • Van Nuffel A, Ariën KK, Stove V, Schindler M, O'Neill E, Schmökel J, Van de Walle I, Naessens E, Vanderstraeten H, Van Landeghem K, Taghon T, Pulkkinen K, Saksela K, Garcia JV, Fackler OT, Kirchhoff F, Verhasselt B. Primate lentiviral Nef proteins deregulate T-cell development by multiple mechanisms. Retrovirology. 2013 Nov 15;10:137. doi: 10.1186/1742-4690-10-137.
  • Falk Hildebrand*, Anh T. L. Nguyen*, Brigitta Brinkman, Roberto Y. Garcia, Benedicte Cauwe, Peter Vandenabeele, Adrian Liston* and Jeroen Raes*. ‘Inflammation-associated enterotypes, host genotype, cage and interindividual effects drive gut microbiota variation in common laboratory mice’. 2013. Genome Biology. 14(1):R4. *Equal contribution first / senior authors.
  • Olga Ucar, Lars-Oliver Tykocinski, James Dooley, Adrian Liston and Bruno Kyewski. ‘An evolutionarily conserved mutual interdependence between Aire and microRNAs in promiscuous gene expression’. 2013. European Journal of Immunology. 43(7) p1769.
  • James Dooley, Michelle Linterman and Adrian Liston. 'MicroRNA regulation of T cell differentiation and function’ 2013. Immunological Reviews. 247(1) p143.
  • Nadia Barizzone, Ine Pauwels, Bernadetta Luciano, Dean Franckaert, Franca Rosa Guerini, Leentje Cosemans, Kelly Hilven, Alessandro Salviati, James Dooley, Dina Danso-Abeam, Alessia di Sapio, Brigitte Decallonne, Chantal Mathieu, Adrian Liston, Maurizio Leone, Bénédicte Dubois, Sandra D’Alfonso and An Goris. ‘No evidence for a role of rare CYP27B1 functional variations in MS’. 2013. Annals of Neurology. 73(3) p433.
  • Veronique Dugas, Genevieve Chabot-Roy, Claudine Beauchamp, Fanny Guimont-Desrochers, Erin E. Hillhouse, Adrian Liston and Sylvie Lesage. ‘Unusual selection and peripheral homeostasis for immunoregulatory CD4-CD8- T cells’. 2013. Immunology. 139(1) p129.
  • Jullie Morscio, Daan Dierickx, Julio Finalet Ferreiro, An Herreman, Peter Van Loo, Emilie Bittoun, Gregor Verhoef, Patrick Matthys, Jan Cools, Iwona Wlodarska, Chris De Wolf-Peeters, Xavier Sagaert, X., Thomas Tousseyn. Gene expression profiling reveals clear differences between EBV-positive and EBV-negative post-transplant lymphoproliferative disorders. 2013. American Journal of Transplantation, 13(5):p1305.
  • Sofie Duraffour, Barbara Mertens, Hermann Meyer, Joost van den Oord, Tania Mitera, Patrick Matthys, Robert Snoeck, Graciela Andrei. Emergence of cowpox: study of the virulence of clinical strains and evaluation of antivirals. 2013. PLoS One, 8(2):e55808.
  • Tim De Schutter, Gracila Andrei, Dimitrios Topalis, Sofie Duraffour, Tania Mitera, Lieve Naesens, Joost van den Oord, Patrick Matthys, Robert Snoeck (2013). Cidofovir treatment improves the pathology caused by the growth of human papillomavirus-positive cervical carcinoma xenografts in athymic nude mice. 2013. Cancer Letters, 28;329(2):137.
  • Stéphanie Put, Steve Schoonooghe, Nick Devoogdt, Evelien Schurgers, Anneleen Avau, Tania Mitera, Matthias D'Huyvetter, Patrick De Baetselier, Geert Raes, Tony Lahoutte, Patrick Matthys. SPECT Imaging of Joint Inflammation with Nanobodies Targeting the Macrophage Mannose Receptor in a Mouse Model for Rheumatoid Arthritis. 2013. Journal of Nuclear Medicine. 54(5) p807.
  • Adrian Liston and Ciro A. Piccirillo. 'Developmental plasticity of murine and human Foxp3 regulatory T cells'. 2013. Advances in Immunology. 119 p85.
  • Wim Pierson, Bénédicte Cauwe, Antonia Policheni, Susan M. Schlenner, Dean Franckaert, Julien Berges, Stephanie Humblet-Baron, Susann Schonefeldt, Marco J. Herold, David Hildeman, Andreas Strasser, Philippe Bouillet, Li-Fan Lu, Patrick Matthys, Antonio A. Freitas, Rita J. Luther, Casey T. Weaver, James Dooley, Daniel H. D. Gray* and Adrian Liston.* ‘Anti-apoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3 regulatory T cells.’ *Co-corresponding authors. 2013. Nature Immunology. 14(9) p959.
  • Kim A. Staats, Susann Schonefeldt, Marike Van Rillaer, Annelies Van Hoecke, Philip Van Damme, Wim Robberecht, Adrian Liston* and Ludo Van Den Bosch*. ‘Beta-2 microglobulin is important for disease progression in a murine model for amyotrophic lateral sclerosis’. *Co-corresponding authors. 2013. Frontiers in Cellular Neuroscience. 7 p249
  • Dina Danso-Abeam, Jianguo Zhang, James Dooley, Kim A. Staats, Lien Van Eyck, Thomas Van Brussel, Shari Zaman, Esther Hauben, Marc Van de Velde, Marie-Anne Morren, Marleen Renard, Christel Van Geet, Heidi Schaballie, Diether Lambrechts, Jinsheng Tao, Dean Franckaert, Stephanie Humblet-Baron, Isabelle Meyts* and Adrian Liston*. ‘Olmsted syndrome: exploration of the immunological phenotype’. *Co-corresponding authors 2013. Orphanet Journal of Rare Diseases. 8:79 doi: 10.1186/1750-1172-8-79.
  • Oliver Brain, Benjamin M. J. Owens, Tica Pichulik, Philip Allan, Elham Khatamzas, Alasdair Leslie, Tessa Steevels, Sameer Sharma, Alice Mayer, Ana Maria Catuneanu, Victoria Morton, Mei-Y Sun, Derek Jewell, Margherita Coccia, Oliver Harrison, Kevin Maloy, Susann Schoenfeldt, Simon Bornschein, Adrian Liston and Alison Simmons. ‘The intracellular sensor NOD2 induces microRNA-29 expression in human dendritic cells to limit IL-23 release’. 2013. Immunity. 39(3) p521.
  • Inês F. Amado, Julien Berges, Rita J. Luther5, Marie-Pierre Mailhé, Sylvie Garcia, Antonio Bandeira, Casey Weaver, Adrian Liston and Antonio A. Freitas. ‘Quorum sensing in CD4 T cell homeostasis: IL-2 coordinates IL-2 producing and regulatory T cell interplay’. 2013. The Journal of Experimental Medicine. 210(12) p2707.
  • Kim A. Staats, Sara Hernandez, Susann Schönefeldt, André Bento-Abreu, James Dooley, Philip Van Damme, Adrian Liston, Wim Robberecht and Ludo Van Den Bosch. ‘Rapamycin increases survival in ALS mice lacking mature lymphocytes’. 2013. Molecular Neurodegeneration. 8(1) p31.
  • Kim A. Staats, Lawrence Van Helleputte, Ashley R. Jones, Andre Bento-Abreu, Annelies Van Hoecke, Aleksey Shatunov, Claire L. Simpson, Robin Lemmens, Tom Jaspers, Kiyoko Fukami, Yoshikazu Nakamura, Robert H. Brown Jr., Philip Van Damme, Adrian Liston, Wim Robberecht, Ammar Al-Chalabi, Ludo Van den Bosch. ‘Genetic ablation of phospholipase C delta 1 increases survival in SODG93A mice’. 2013. Neurobiology of Disease. 60C p11.
  • Valérie Hox, Jeroen A. Vanoirbeek, Yeranddy A. Alpizar, Sabrina Voedisch, Ina Callebaut, Sonja Bobic, Ali Sharify, Vanessa De Vooght, Laura Van Gerven, Adrian Liston, Dominique M. A. Bullens, Jan L. Ceuppens, Annick De Vries, Peter Hoet, Armin Braun, Karel Talavera, Benoit Nemery and Peter W. Hellings. ‘TRPA1 and mast cell activation induce non-allergic airway hyperreactivity in mice’. 2013. American Journal of Respiratory and Critical Care Medicine. 187(5) p486.
  • Magali Irla, Lucia Guerri, Jeanne Guenot, Arnauld Serge, Olivier Lantx, Adrian Liston, Beat A Imhof, Ed Palmer and Walter Reith. ‘Control of thymic medulla expansion and homeostasis by autoreactive CD4 thymocytes’. 2013. PLOS One. 7(12) e52591.
  • Tim De Schutter, Graciela Andrei, Dimitrios Topalis, Sophie Duraffour, Tania Mitera, Joost van den Oord, Patrick Matthys and Robert Snoeck. ‘Reduced tumorigenicity and pathogenicity of cervical carcinoma SiHa cells selected for resistance to cidofovir’. 2013. Molecular Cancer. 12 p158.
  • Broux B, Stinissen P, Hellings N. Which immune cells matter? The immunopathogenesis of multiple sclerosis. Crit Rev Immunol. 2013;33(4):283-306. (IF: 3.383)
  • Russo V, Pilla L, Lunghi F, Crocchiolo R, Greco R, Ciceri F, Maggioni D, Fontana R, Mukenge S, Rivoltini L, Rigamonti G, Mercuri SR, Nicoletti R, Maschio AD, Gianolli L, Fazio F, Marchianò A, Florio AD, Maio M, Salomoni M, Gallo-Stampino C, Fiacco MD, Lambiase A, Coulie PG, Patuzzo R, Parmiani G, Traversari C, Bordignon C, Santinami M, Bregni M. Clinical and immunologic responses in melanoma patients vaccinated with MAGE-A3-genetically modified lymphocytes. Int J Cancer. 2013 Jun 1;132(11):2557-66.
  • Palmeira L, Sorel O, Van Campe W, Boudry C, Roels S, Myster F, Reschner A, Coulie PG, Kerkhofs P, Vanderplasschen A, Dewals BG. An essential role for γ-herpesvirus latency-associated nuclear antigen homolog in an acute lymphoproliferative disease of cattle. Proc Natl Acad Sci U S A. 2013 May 21;110(21):E1933-42.
  • Tel J, Aarntzen EH, Baba T, Schreibelt G, Schulte BM, Benitez-Ribas D, Boerman OC, Croockewit S, Oyen WJ, van Rossum M, Winkels G, Coulie PG, Punt CJ, Figdor CG, de Vries IJ. Natural human plasmacytoid dendritic cells induce antigen-specific T-cell responses in melanoma patients. Cancer Res. 2013 Feb 1;73(3):1063-75. doi: 10.1158/0008-5472.CAN-12-2583. Epub 2013 Jan 23.
  • Baeck M, Soria A, Marot L, Theate I, Hendrickx E, Van Belle A, Goossens A, Tennstedt D, Dachelet C, Jaeger J, Pilette C, Renauld JC, Van Baren N, Rozières A, Nicolas JF, Dumoutier L. Characterization of the T cell response in allergic contact dermatitis caused by corticosteroids. Contact Dermatitis. 2013 Jun;68(6):357-368.
  • Couturier M, Lamarthée B, Arbez J, Renauld JC, Bossard C, Malard F, Bonnefoy F, Mohty M, Perruche S, Tiberghien P, Saas P, Gaugler B. IL-22 deficiency in donor T cells attenuates murine acute graft-versus-host disease mortality while sparing the graft-versus-leukemia effect. Leukemia. 2013 Feb 12.
  • Toussaint M, Fievez L, Drion PV, Cataldo D, Bureau F, Lekeux P, Desmet CJ. Myeloid hypoxia-inducible factor 1α prevents airway allergy in mice through macrophage-mediated immunoregulation. Mucosal Immunol. 2013 May;6(3):485-97.
  • Filtjens J, Taveirne S, Van Acker A, Van Ammel E, Vanhees M, Kerre T, Taghon T, Vandekerckhove B, Plum J, Leclercq G. Abundant stage-dependent Ly49E expression by liver NK cells is not essential for their differentiation and function. J Leukoc Biol. 2013 May;93(5):699-711. doi: 10.1189/jlb.0812378.
  • Snauwaert S, Vandekerckhove B, Kerre T. Can immunotherapy specifically target acute myeloid leukemic stem cells? Oncoimmunology. 2013 Feb 1;2(2):e22943.
  • Dina Danso-Abeam, Kim A. Staats, Dean Franckaert, Ludo Van Den Bosch, Adrian Liston, Daniel H. D. Gray* and James Dooley*. ‘Aire mediates thymic expression and tolerance of pancreatic antigens via an unconventional transcriptional mechanism’. 2012. European Journal of Immunology. 43(1) p75. *Co-corresponding authors.
  • Gomez AM, Vanheel A, Losen M, Molenaar PC, De Baets MH, Noben JP, Hellings N, Martinez-Martinez P. Proteomic analysis of rat tibialis anterior muscles at different stages of experimental autoimmune myasthenia gravis. J Neuroimmunol. 2013 Jun 18.
  • Carmans S, Hendriks JJ, Slaets H, Thewissen K, Stinissen P, Rigo JM, Hellings N. Systemic treatment with the inhibitory neurotransmitter γ-aminobutyric acid aggravates experimental autoimmune encephalomyelitis by affecting proinflammatory immune responses. J Neuroimmunol. 2013 Feb 15;255(1-2):45-53.
2012
  • Welsby I, Hutin D, Leo O. Complex roles of members of the ADP-ribosyl transferase super family in immune defences: looking beyond PARP1. Biochem Pharmacol. 2012 Jul 1;84(1):11-20.
  • Wilmar A, Lonez C, Vermeersch M, Andrianne M, Pérez-Morga D, Ruysschaert JM, Vandenbranden M, Leo O, Temmerman ST. The cationic lipid, diC14 amidine, extends the adjuvant properties of aluminum salts through a TLR-4- and caspase-1-independent mechanism. Vaccine. 2012 Jan 5;30(2):414-24.
  • Wathelet N, Moser M. Role of dendritic cells in the regulation of antitumor immunity. Oncoimmunology. 2013 Apr 1;2(4):e23973.
  • Hespel C, Moser M. Role of inflammatory dendritic cells in innate and adaptive immunity. Eur J Immunol. 2012 Oct;42(10):2535-43.
  • Salmon D, Vanwalleghem G, Morias Y, Denoeud J, Krumbholz C, Lhommé F, Bachmaier S, Kador M, Gossmann J, Dias FB, De Muylder G, Uzureau P, Magez S, Moser M, De Baetselier P, Van Den Abbeele J, Beschin A, Boshart M, Pays E. Adenylate cyclases of Trypanosoma brucei inhibit the innate immune response of the host. Science. 2012 Jul 27;337(6093):463-6.
  • Rahir G, Moser M. Tumor microenvironment and lymphocyte infiltration. Cancer Immunol Immunother. 2012 Jun;61(6):751-9.
  • Van Nuffel AM, Wilgenhof S, Thielemans K, Bonehill A. Overcoming HLA restriction in clinical trials: Immune monitoring of mRNA-loaded DC therapy. Oncoimmunology. 2012 Nov 1;1(8):1392-1394.
  • Aarntzen EH, Schreibelt G, Bol K, Lesterhuis WJ, Croockewit AJ, de Wilt JH,van Rossum MM, Blokx WA, Jacobs JF, Duiveman-de Boer T, Schuurhuis DH, Mus R, Thielemans K, de Vries IJ, Figdor CG, Punt CJ, Adema GJ. Vaccination with mRNA-electroporated dendritic cells induces robust tumor antigen-specific CD4 and CD8 T cells responses in stage III and IV melanoma patients. Clin Cancer Res. 2012 Oct 1;18(19):5460-70.
  • Snauwaert S, Vanhee S, Goetgeluk G, Verstichel G, Van Caeneghem Y, Velghe I, Philippé J, Berneman ZN, Plum J, Taghon T, Leclercq G, Thielemans K, Kerre T, Vandekerckhove B. RHAMM/HMMR (CD168) is not an ideal target antigen for immunotherapy of acute myeloid leukemia. Haematologica. 2012 Oct;97(10):1539-47.
  • Speeckaert R, Vermaelen K, van Geel N, Autier P, Lambert J, Haspeslagh M, van Gele M, Thielemans K, Neyns B, Roche N, Verbeke N, Deron P, Speeckaert M, Brochez L. Indoleamine 2,3-dioxygenase, a new prognostic marker in sentinel lymph nodes of melanoma patients. Eur J Cancer. 2012 Sep;48(13):2004-11.
  • De Keersmaecker B, Allard SD, Lacor P, Schots R, Thielemans K, Aerts JL. Expansion of polyfunctional HIV-specific T cells upon stimulation with mRNA electroporated dendritic cells in the presence of immunomodulatory drugs. J Virol. 2012 Sep;86(17):9351-60. doi: 10.1128/JVI.00472-12.
  • Emeagi PU, Thielemans K, Breckpot K. The role of SMAC mimetics in regulation of tumor cell death and immunity. Oncoimmunology. 2012 Sep 1;1(6):965-967.
  • Van Nuffel AM, Benteyn D, Wilgenhof S, Corthals J, Heirman C, Neyns B, Thielemans K, Bonehill A. Intravenous and intradermal TriMix-dendritic cell therapy results in a broad T-cell response and durable tumor response in a chemorefractory stage IV-M1c melanoma patient. Cancer Immunol Immunother. 2012 Jul;61(7):1033-43.
  • Van Nuffel AM, Benteyn D, Wilgenhof S, Pierret L, Corthals J, Heirman C, van der Bruggen P, Coulie PG, Neyns B, Thielemans K, Bonehill A. Dendritic cells loaded with mRNA encoding full-length tumor antigens prime CD4 and CD8 T cells in melanoma patients. Mol Ther. 2012 May;20(5):1063-74. doi: 10.1038/mt.2012.11.
  • Van Lint S, Goyvaerts C, Maenhout S, Goethals L, Disy A, Benteyn D, Pen J, Bonehill A, Heirman C, Breckpot K, Thielemans K. Preclinical evaluation of TriMix and antigen mRNA-based antitumor therapy. Cancer Res. 2012 Apr 1;72(7):1661-71.
  • Van Nuffel AM, Tuyaerts S, Benteyn D, Wilgenhof S, Corthals J, Heirman C, Neyns B, Thielemans K, Bonehill A. Epitope and HLA-type independent monitoring of antigen-specific T-cells after treatment with dendritic cells presenting full-length tumor antigens. J Immunol Methods. 2012 Mar 30;377(1-2):23-36.
  • Emeagi PU, Van Lint S, Goyvaerts C, Maenhout S, Cauwels A, McNeish IA, Bos T, Heirman C, Thielemans K, Aerts JL, Breckpot K. Proinflammatory characteristics of SMAC/DIABLO-induced cell death in antitumor therapy. Cancer Res. 2012 Mar 15;72(6):1342-52.
  • Allard SD, De Keersmaecker B, de Goede AL, Verschuren EJ, Koetsveld J, Reedijk ML, Wylock C, De Bel AV, Vandeloo J, Pistoor F, Heirman C, Beyer WE, Eilers PH, Corthals J, Padmos I, Thielemans K, Osterhaus AD, Lacor P, van der Ende ME, Aerts JL, van Baalen CA, Gruters RA. A phase I/IIa immunotherapy trial of HIV-1-infected patients with Tat, Rev and Nef expressing dendritic cells followed by treatment interruption. Clin Immunol. 2012 Mar;142(3):252-68.
  • Thielemans K, Tsoumpas C, Mustafovic S, Beisel T, Aguiar P, Dikaios N, Jacobson MW. STIR: software for tomographic image reconstruction release 2. Phys Med Biol. 2012 Feb 21;57(4):867-83.
  • Zhu S, Van den Eynde BJ, Coulie PG, Li YF, El-Gamil M, Rosenberg SA, Robbins PF. Characterization of T-cell receptors directed against HLA-A*01-restricted and C*07-restricted epitopes of MAGE-A3 and MAGE-A12. J Immunother. 2012 Nov-Dec;35(9):680-8.
  • Vermeire S, Carbonnel F, Coulie PG, Geenen V, Hazes JM, Masson PL, De Keyser F, Louis E. Management of inflammatory bowel disease in pregnancy. J Crohns Colitis. 2012 Sep;6(8):811-23.
  • Cipponi A, Mercier M, Seremet T, Baurain JF, Théate I, van den Oord J, Stas M, Boon T, Coulie PG, van Baren N. Neogenesis of lymphoid structures and antibody responses occur in human melanoma metastases. Cancer Res. 2012 Aug 15;72(16):3997-4007.
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  • Aikaterini S. Papadopoulou#, James Dooley#*, Michelle A. Linterman, Wim Pierson, Olga Ucar, Bruno Kyewski, Saulius Zuklys, Georg A. Hollander, Patrick Matthys, Daniel H. Gray, Bart De Strooper and Adrian Liston. #Equal first authors. *Co-corresponding authors. 'The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor.' 2012. Nature Immunology. 13 p181.
  • Stephanie Put, Anneleen Avau, Stephanie Humblet-Baron, Evelien Schurgers, Adrian Liston* and Patrick Matthys. *Corresponding author. 'Macrophages have no lineage history of Foxp3 expression'. 2012. Blood. 119(5) p1316.
  • Michelle Linterman, Adrian Liston and Carola G. Vinuesa. 'Follicular helper T cell differentiation and the co-option of this pathway by non-helper cells' 2012. Immunological Reviews. 247(1) p143.
  • Valérie Hox, Jeroen A. Vanoirbeek, Yeranddy A. Alpizar, Sabrina Voedisch, Ina Callebaut, Sonja Bobic, Ali Sharify, Vanessa De Vooght, Laura Van Gerven, Adrian Liston, Dominique M. A. Bullens, Jan L. Ceuppens, Annick De Vries, Peter Hoet, Armin Braun, Karel Talavera, Benoit Nemery and Peter W. Hellings. ‘TRPA1 and mast cell activation induce non-allergic airway hyperreactivity in mice’. 2012. American Journal of Respiratory and Critical Care Medicine. 187(5) p486.
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  • James Dooley* and Adrian Liston*. 'Molecular control over thymic involution: from cytokines and microRNA to aging and adipose tissue' 2012. European Journal of Immunology. 42(5) p1073. *Co-corresponding authors.
  • Lei Tian, Stephanie Humblet-Baron* and Adrian Liston*. 'Immune Tolerance: Are Regulatory T cell subsets needed to explain suppression of autoimmunity?" 2012. Bioessays. 34(7) p569. *Co-corresponding authors.
  • Adrian Liston, Aikaterini S Papadopoulou, Dina Danso-Abeam and James Dooley. ‘MicroRNA-29 in the adaptive immune system: setting the threshold’. 2012. Cellular and Molecular Life Sciences. 69(21) p3533.
  • Paola Romagnoli, James Dooley, Genevieve Enault, Rita Vicente, Bernard Malissen, Adrian Liston and Joost P. M. van Meerwijk. ‘The thymic niche does not limit development of the naturally diverse population of mouse regulatory T lymphocytes’. 2012. Journal of Immunology. 189(8) p3831.
  • Saulius Zuklys, Carlos E. Mayer, Saule Zhanybekova, Heather Stefanski, Gretel Nusspaumer, Jason Gill, Thomas Barthlott, Stephan Chappaz, Takeshi Nitta, James Dooley, Ruben Nogales-Cadenas, Yousuke Takahama, Daniela Finke, Adrian Liston, Bruce R. Blazar, Alberto Pascual-Montano and Georg A. Holländer. ‘MiRNAs control the maintenance of thymic epithelia and their competence for T lineage commitment and thymocyte selection’. 2012. Journal of Immunology. 189(8) p3894.
  • Magali Irla, Lucia Guerri, Jeanne Guenot, Arnauld Serge, Olivier Lantx, Adrian Liston, Beat A Imhof, Ed Palmer and Walter Reith. ‘Control of thymic medulla expansion and homeostasis by autoreactive CD4 thymocytes’. 2012. PLOS One. 7(12) e52591.
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